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Thread: Enjoy your cuppa java!

  1. #1
    Distinguished Community Member SuzE-Q's Avatar
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    Lightbulb Enjoy your cuppa java!

    A lot of them!

    http://www.ncbi.nlm.nih.gov/pubmed/25019206

    Neuropharmacology. 2014 Jul 11. pii: S0028-3908(14)00267-6. doi: 10.1016/j.neuropharm.2014.06.029. [Epub ahead of print]

    Chronic Caffeine Treatment Protects Against Experimental Autoimmune Encephalomyelitis in Mice: Therapeutic Window and Receptor Subtype Mechanism.

    Wang T1, Xi NN1, Chen Y1, Shang XF1, Hu Q1, Chen JF2, Zheng RY3.


    Abstract
    Chronic treatment with caffeine, the most widely consumed psychoactive drug and a non-selective antagonist of adenosine receptors, can protection against myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). In this study, we investigated the mechanism underlying caffeine-mediated neuroprotection against EAE by determining the effective therapeutic time-window of caffeine and the involvement of adenosine A2A and A1 receptor. We found that administration of caffeine during the effector phase (10→20 days post-immunization, d.p.i., corresponding to appearance of neurological deficits) but not the induction phase (0→10 d.p.i., before the appearance of ascending flaccid paralysis) significantly ameliorated EAE-induced neurobehavioral deficits, reduced the infiltration of inflammatory cells into the spinal cord and reduced the demyelination of spinal cord. Furthermore, genetic deletion of the A2AR exacerbated MOG-induced brain damage and caffeine administering to A2AR knockout mice reversed this EAE pathology by acting at non-A2AR target. The protective effect of chronic caffeine treatment was associated with up-regulation of brain A1R (but not A2AR). The identification of the effective therapeutic window of caffeine at the effector phase and clarification of non-A2AR target (likely A1R) in caffeine action in EAE models advance the therapeutic prospective that chronic caffeine consumption may attenuate brain damage in MS.

  2. #2
    Distinguished Community Member agate's Avatar
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    I don't function nearly as well without my daily caffeine. I get mine in Diet Pepsi or Diet Coke, sometimes in coffee. I'm trying to develop more of a liking for coffee but one cup of it sometimes makes me jittery.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  3. #3
    Distinguished Community Member Frog42's Avatar
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    Must have my morning coffee. Glad to know this!


    Whatever happens around you, don't take it personally. Nothing other people do is because of you. It is because of themselves. -- Miguel Ruiz

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    Distinguished Community Member jendie's Avatar
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    I do enjoy my daily cup of ... this is how I look when I've had too much....

    I like coffee, you like coffee, let's get some coffee!

    Jendie
    I've been a member of this forum during its different incarnations since I was dx in 9/98


  5. #5
    Distinguished Community Member Howie's Avatar
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    Cool

    Wasn't Java the Cup in Star Wars?
    Roswell was a gift.

  6. #6
    Distinguished Community Member Frog42's Avatar
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    Quote Originally Posted by Howie View Post
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    Wasn't Java the Cup in Star Wars?


    Whatever happens around you, don't take it personally. Nothing other people do is because of you. It is because of themselves. -- Miguel Ruiz

  7. #7
    Distinguished Community Member renee's Avatar
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    Well, I guess I can have a cup of the real stuff once a day if I want.
    Or stick to chocolate.

  8. #8
    Distinguished Community Member agate's Avatar
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    Quote Originally Posted by renee View Post
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    Well, I guess I can have a cup of the real stuff once a day if I want.
    Or stick to chocolate.
    Or try both.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  9. #9

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    I Love my Coffee. I use to drink coffee all day long. I have cut it down to two cups. and no caffeine past 4:00 in the afternoon, or I'll be running to the bathroom all night. and I need my sleep.

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