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Thread: PML in European drug Fumerate

  1. #1
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    Default PML in European drug Fumerate

    The New England Journal of Medicine reports 2 cases of PML in the European psoriasis drug that is the main ingredient in Tecfidera (BG-12).

    Read here: http://www.foxbusiness.com/news/2013...ain-infection/

    And here at Medline: http://www.medpagetoday.com/Neurolog...ews_2013-04-24

    Note: links no longer work as they were "breaking news." Now they are "News" or "Business News." I hate that business news. In any event, just google the thread title to find many more.
    ANN
    Last edited by stillstANNding; 04-25-2013 at 07:02 AM. Reason: Links changed
    There comes a time when silence is betrayal.- MLK

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    Distinguished Community Member agate's Avatar
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    Let's see, this is the stuff that didn't work well on sofas and so they thought they'd try it on people. You never know when you might come up with a winner, I guess.

    Except that now it looks as if dimethyl fumarate has its drawbacks in people.

    I'm sorry but I have to wonder if Biogen Idec has the best interests of people with MS at heart. It's looking more and more as if first this and then that is being thrown our way on the offchance that something might help. (Hey, you never know.)
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    Distinguished Community Member Frog42's Avatar
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    Quote Originally Posted by agate View Post
    This quote is hidden because you are ignoring this member. Show Quote
    I'm sorry but I have to wonder if Biogen Idec has the best interests of people with MS at heart.
    I've never even entertained that idea. I honestly believe their only interest is profit.


    Whatever happens around you, don't take it personally. Nothing other people do is because of you. It is because of themselves. -- Miguel Ruiz

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    Oh my!! How could we ever think that Biogen does not have only our "best health interest at heart"? I am sure no one would think they are interested in our
    pocketbooks.
    Virginia

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    Distinguished Community Member agate's Avatar
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    I was being more than a little sarcastic.

    I am sure no one would think they are interested in our
    pocketbooks.
    Or, better yet, in our insurance companies' pocketbooks. They're the people with the deep pockets. Would these costly MS drugs even exist if it weren't for the insurance companies standing by?

    Or maybe they'd exist--but at a much lower cost.... Hmm.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    Many people were counting on this drug and may have even "needed" it. We have among us people that can no longer use needles because of dexterity or no site left for injections. It is sad news.

    That's not to say that Biogen doesn't want your money.
    ANN
    There comes a time when silence is betrayal.- MLK

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    Distinguished Community Member agate's Avatar
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    It is very sad indeed. Guess we can hope that the other oral medicines that are coming along will be a better solution.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  8. #8
    Distinguished Community Member agate's Avatar
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    stillstANNding, your links are working for me. There's another story on Bloomberg.com:

    http://www.bloomberg.com/news/2013-0...n-disease.html
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  9. #9
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    Default PML

    You know the friend that I have mentioned who has been on T for the longest time and has tested positive for JC virus has also been told by her neuro that he wants to take her off T and start her on Fumerate. If it also can cause PML why would he recommend it to her since she also has the JC virus?

    I wonder how much stock in Biogen, Idec the neuro has bought? Shouldn't that be considered "a conflict of interest"? I think it would be in any other profession. Does anyone know the answer to that question?

    Every time I go to the MS Center I see the drug rep from Biogen.....a very cozy arrangement......and an opportunity for insider knowledge ....."you got to know when to hold them and know when to fold them" as the Kenny Rogers song goes....

    Blessings,
    Gabriella
    Progressive/Relapsing MS, Myasthenia Gravis, Spinal Stenosis, Degenerative Disc Disease, Diabetes, Hypertension, Hashimoto's Thyroiditis
    Advocate for ADA, Artist's Community for Change, ADAPT, Universal Living in Place, HopeKeepers, Complementary and Alternative Medicine

    "Life is mostly froth and bubble, two things stand like stone. Kindness in another's trouble, Courage in your own"........Adam Lindsay Gordon

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    Distinguished Community Member agate's Avatar
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    Gabriella, maybe your friend's doctor is rethinking that advice at this point. Or no?

    I wonder how much stock in Biogen, Idec the neuro has bought? Shouldn't that be considered "a conflict of interest"? I think it would be in any other profession. Does anyone know the answer to that question?
    I don't know but it's a good question.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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