CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE BLEW IT’




10/31/2012



Managing Future Risks from BSE and other Emerging Issues



Summary Report of a Foresight Exercise



Background Canada’s cattle industry experienced a severe shock with the finding of several cases of Bovine Spongiform Encephalopathy (BSE) in native-born cattle starting in 2003. The first case in a Canadian-born animal was reported in May 2003. Since then, a total of 19 cases of BSE have been found in Canadian cattle, with the latest case detected in February 2011 in a dairy cow born in 2004.


Lucrative export markets proved fragile resulting in very significant economic losses despite the industry’s success maintaining reasonable stability in domestic markets. The cost of market closures and the subsequent actions taken to sustain the Canadian cattle and beef industries has been variously estimated to exceed $10 billion.


Seventeen of Canada’s BSE cases (10 dairy, three beef-cross and four beef) were of the “classical” type of BSE (c-BSE), the form responsible for the vast majority of cases in most BSE-affected countries. The other two (both beef animals) were “atypical” cases as they occurred in significantly older animals, but had slightly different biochemical characteristics from the classic form. Observations in other BSE-affected countries and ongoing research indicate that that atypical cases might represent spontaneous forms of BSE. Uncertainties remain regarding the implications of these atypical cases for both the human food supply and the animal feed chain.


While the situation has improved significantly, Canada faces ongoing challenges to the design and costs of its BSE prevention programs and to international recognition of its BSE status:


1. Two major beef exporting countries (Mexico and the USA) that now share Canada’s “controlled risk” status for BSE might advance to “negligible risk” status some years before Canada, thereby gaining trade advantages. Brazil, the world`s largest beef exporting country, recently was reclassified by the World Organization for Animal Health (OIE) from ``controlled risk`` to ``negligible risk`` status for BSE.


2. There are unresolved conflicts between pressures on the one hand to harmonize feed control standards with the USA in order to stay cost-competitive and, on the other hand, to accelerate measures to gain international recognition of Canada’s BSE status as ``negligible risk``:


a. Canada’s regime to safely dispose of specified risk materials (SRM) is more demanding and costly than that of the USA, but it is still less stringent than those of the most demanding countries (EU, Japan).


b. Canada’s feed control regime is less rigorous than some others (EU, Japan) and has been criticized by the OIE for its lack of a testing program and for limited stringency of rendering practices.


3. BSE surveillance in Canada has declined from 55,000 animals tested in 2007 to about 35,000 animals per year more recently. Is this level sufficiently robust to support the case that will need to be made for recognition of Canada as a “negligible risk” country?


4. There remain uncertainties about other prion diseases that are known to occur in Canada: chronic wasting disease (CWD) and scrapie. In the case of CWD, uncertainties about the potential host range combined with the ongoing spread of the CWD agent in the environment of Western Canada may provide arguments for trading partners who might wish to maintain or raise protective barriers.




The Foresight Exercise To assist in planning for the management of these and future risks to the industries of similar magnitude, two Workshops were convened to explore possible future scenarios using a Foresight process. Participants were drawn from the cattle and beef industries, academia and governments, including regulatory agencies. Further information on these Workshops is provided in Appendices 1 to 4.




snip...



Appendix 4: Scenario Stories



The following is a summary of the scenarios developed by Workshop 1 participants.




SCENARIO 1: ‘BLUE SKIES’

Sustainable Production and Robust Markets

Canada

Science

- Affirmed the health benefits of beef in balanced diets.

- Produced a cost-effective test for BSE and other diseases that is widely used, providing input for a nation-wide data system. The system enables comprehensive surveillance of the health of Canada’s herd, increasing consumer confidence.

- Developed and validated more cost-effective methods to safely manage SRM

- Government and private investment from industries, led to significant breakthroughs in TSE (transmissible spongiform encephalopathy) science and genetic research in feed grains, forage and cattle.



SCENARIO 2: ‘BOVINE SITUATION EXTREME’

Unsustainable Production and Fragile Markets

Canada

Science

- Financial support has weakened due to financial problems of Government and the industries, leading to sharp curtailments of research.

- Work on a vaccine for the variant TSE continues feverishly.

- No major scientific breakthroughs related to the prevention and cure of prion diseases occurred.




SCENARIO 3: ‘THE THIN STEMMED GLASS’

Sustainable Production and Fragile Markets

Canada

Science

- BSE is not linked to classical CJD, but a TSE is found that is linked to Alzheimer’s disease.

- Science breakthroughs in neurodegenerative diseases.

- New product development continues.




SCENARIO 4: ‘WE HAD OUR CHANCE AND WE BLEW IT’

Unsustainable Production and Robust Markets

Canada

Science

- Experimental evidence indicates that abnormal prions may persist for undetermined periods of time in buried materials.

- A new prion disease has occurred in cattle, possibly originated from CWD. Research funds are not available to investigate its nature and origin.

- The origin, transmission and prevalence of atypical BSE remain unclear.

- L-type atypical BSE has been demonstrated to be transmissible to humans.

- New testing procedures indicate the presence of sub-clinical carriers in the cattle population.

- New scientific knowledge provides no evidence that CWD is transmissible from Cervids to humans.



http://www.prioninstitute.ca/forms/B...ture_Risks.pdf




Tuesday, November 6, 2012

Transmission of New Bovine Prion to Mice, Atypical Scrapie, BSE, and Sporadic CJD, November-December 2012 update

http://transmissiblespongiformenceph...-prion-to.html





SUMMARY REPORT CALIFORNIA BOVINE SPONGIFORM ENCEPHALOPATHY CASE INVESTIGATION JULY 2012

Summary Report BSE 2012

Executive Summary

http://transmissiblespongiformenceph...ia-bovine.html




Saturday, August 4, 2012

Final Feed Investigation Summary - California BSE Case - July 2012

http://transmissiblespongiformenceph...n-summary.html




Saturday, August 4, 2012

Update from APHIS Regarding Release of the Final Report on the BSE Epidemiological Investigation

http://transmissiblespongiformenceph...elease-of.html





Tuesday, November 02, 2010

BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367) statutory (obex only) diagnostic criteria CVL 1992

http://bse-atypical.blogspot.com/201...tion-rbse.html





Thursday, June 14, 2012

R-CALF USA Calls USDA Dishonest and Corrupt; Submits Fourth Request for Extension

R-CALF United Stockgrowers of America

http://madcowusda.blogspot.com/2012/...onest-and.html




Monday, June 18, 2012 R-CALF

Submits Incomplete Comments Under Protest in Bizarre Rulemaking “Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products”

http://madcowusda.blogspot.com/2012/...-comments.html




CENSORSHIP IS A TERRIBLE THING $$$




Canada has had a COVER-UP policy of mad cow disease since about the 17th case OR 18th case of mad cow disease. AFTER THAT, all FOIA request were ignored $$$


THIS proves there is indeed an epidemic of mad cow disease in North America, and it has been covered up for years and years, if not for decades, and it’s getting worse $$$


http://www.inspection.gc.ca/english/.../comenqe.shtml




Thursday, February 10, 2011

TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY REPORT UPDATE CANADA FEBRUARY 2011 and how to hide mad cow disease in Canada Current as of: 2011-01-31

http://madcowtesting.blogspot.com/20...halopathy.html




Wednesday, August 11, 2010

REPORT ON THE INVESTIGATION OF THE SIXTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bse-atypical.blogspot.com/201...sixteenth.html




Thursday, August 19, 2010

REPORT ON THE INVESTIGATION OF THE SEVENTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bseusa.blogspot.com/2010/08/r...venteenth.html




Friday, March 4, 2011

Alberta dairy cow found with mad cow disease

http://transmissiblespongiformenceph...h-mad-cow.html





Tuesday, June 26, 2012

Creutzfeldt Jakob Disease Human TSE report update North America, Canada, Mexico, and USDA PRION UNIT as of May 18, 2012

type determination pending Creutzfeldt Jakob Disease (tdpCJD), is on the rise in Canada and the USA

http://creutzfeldt-jakob-disease.blo...human-tse.html




Wednesday, June 13, 2012

MEXICO IS UNDER or MIS DIAGNOSING CREUTZFELDT JAKOB DISEASE AND OTHER PRION DISEASE SOME WITH POSSIBLE nvCJD

http://creutzfeldt-jakob-disease.blo...iagnosing.html




Wednesday, April 4, 2012

Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products APHIS-2008-0010-0008 RIN:0579-AC68

http://transmissiblespongiformenceph...halopathy.html



Thursday, February 16, 2012

Bovine Spongiform Encephalopathy BSE

31 USA SENATORS ASK PRESIDENT OBAMA TO HELP SPREAD MAD COW DISEASE 2012

http://transmissiblespongiformenceph...hy-bse-31.html




Wednesday, February 16, 2011

IN CONFIDENCE

SCRAPIE TRANSMISSION TO CHIMPANZEES

IN CONFIDENCE

http://scrapie-usa.blogspot.com/2011...ission-to.html




Sunday, April 18, 2010

SCRAPIE AND ATYPICAL SCRAPIE TRANSMISSION STUDIES A REVIEW 2010

http://scrapie-usa.blogspot.com/2010...l-scrapie.html




Thursday, March 29, 2012

atypical Nor-98 Scrapie has spread from coast to coast in the USA 2012

NIAA Annual Conference April 11-14, 2011San Antonio, Texas

http://nor-98.blogspot.com/2012/03/a...read-from.html



Thursday, February 23, 2012

Atypical Scrapie NOR-98 confirmed Alberta Canada sheep January 2012

http://transmissiblespongiformenceph...confirmed.html




Wednesday, April 4, 2012

20120402 - Breach of quarantine/Violation de la mise en quarantaine of an ongoing Scrapie investigation

http://transmissiblespongiformenceph...violation.html




Monday, June 11, 2012

another atypical Nor-98 Scrapie case documented in Canada for 2012

http://nor-98.blogspot.com/2012/06/a...apie-case.html




Monday, April 25, 2011

Experimental Oral Transmission of Atypical Scrapie to Sheep

Volume 17, Number 5-May 2011 However, work with transgenic mice has demonstrated the potential susceptibility of pigs, with the disturbing finding that the biochemical properties of the resulting PrPSc have changed on transmission (40).

http://nor-98.blogspot.com/2011/04/e...ission-of.html




***The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.

http://www.prion2007.com/pdf/Prion%2...0Abstracts.pdf




*** Intriguingly, these conclusions suggest that some pathological features of Nor98 are reminiscent of Gerstmann-Sträussler-Scheinker disease.

119

http://www.neuroprion.com/pdf_docs/c...tract_book.pdf





*** These observations support the view that a truly infectious TSE agent, unrecognized until recently, infects sheep and goat flocks and may have important implications in terms of scrapie control and public health.

http://www.pnas.org/content/102/44/16031.abstract




Surprisingly the TSE agent characteristics were dramatically different v/hen passaged into Tg bovine mice. The recovered TSE agent had biological and biochemical characteristics similar to those of atypical BSE L in the same mouse model. Moreover, whereas no other TSE agent than BSE were shown to transmit into Tg porcine mice, atypical scrapie was able to develop into this model, albeit with low attack rate on first passage.

Furthermore, after adaptation in the porcine mouse model this prion showed similar biological and biochemical characteristics than BSE adapted to this porcine mouse model. Altogether these data indicate.

(i) the unsuspected potential abilities of atypical scrapie to cross species barriers

(ii) the possible capacity of this agent to acquire new characteristics when crossing species barrier

These findings raise some interrogation on the concept of TSE strain and on the origin of the diversity of the TSE agents and could have consequences on field TSE control measures.

http://www.neuroprion.org/resources/...-prion2008.pdf




Friday, February 11, 2011

Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues

http://nor-98.blogspot.com/2011/02/a...tivity-in.html




Monday, November 30, 2009

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

http://nor-98.blogspot.com/2009/11/u...o-exclude.html

I strenuously urge the USDA and the OIE et al to revoke the exemption of the legal global trading of atypical Nor-98 scrapie TSE. ...TSS




Thursday, November 29, 2012

Chronic wasting disease on the Canadian prairies

http://chronic-wasting-disease.blogs...-canadian.html





Tuesday, November 13, 2012

PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD

http://chronic-wasting-disease.blogs...pe-of-cwd.html





Wednesday, November 14, 2012

PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD INVESTIGATION MOVES INTO LOUISIANA and INDIANA

http://chronic-wasting-disease.blogs...of-cwd_14.html





Friday, November 09, 2012

Chronic Wasting Disease CWD in cervidae and transmission to other species

http://chronic-wasting-disease.blogs...-cervidae.html



http://chronic-wasting-disease.blogspot.com/




OR-10: Variably protease-sensitive prionopathy is transmissible in bank voles

Romolo Nonno,1 Michele Di Bari,1 Laura Pirisinu,1 Claudia D’Agostino,1 Stefano Marcon,1 Geraldina Riccardi,1 Gabriele Vaccari,1 Piero Parchi,2 Wenquan Zou,3 Pierluigi Gambetti,3 Umberto Agrimi1 1Istituto Superiore di Sanità; Rome, Italy; 2Dipartimento di Scienze Neurologiche, Università di Bologna; Bologna, Italy; 3Case Western Reserve University; Cleveland, OH USA


Background. Variably protease-sensitive prionopathy (VPSPr) is a recently described “sporadic”neurodegenerative disease involving prion protein aggregation, which has clinical similarities with non-Alzheimer dementias, such as fronto-temporal dementia. Currently, 30 cases of VPSPr have been reported in Europe and USA, of which 19 cases were homozygous for valine at codon 129 of the prion protein (VV), 8 were MV and 3 were MM. A distinctive feature of VPSPr is the electrophoretic pattern of PrPSc after digestion with proteinase K (PK). After PK-treatment, PrP from VPSPr forms a ladder-like electrophoretic pattern similar to that described in GSS cases. The clinical and pathological features of VPSPr raised the question of the correct classification of VPSPr among prion diseases or other forms of neurodegenerative disorders. Here we report preliminary data on the transmissibility and pathological features of VPSPr cases in bank voles.


Materials and Methods. Seven VPSPr cases were inoculated in two genetic lines of bank voles, carrying either methionine or isoleucine at codon 109 of the prion protein (named BvM109 and BvI109, respectively). Among the VPSPr cases selected, 2 were VV at PrP codon 129, 3 were MV and 2 were MM. Clinical diagnosis in voles was confirmed by brain pathological assessment and western blot for PK-resistant PrPSc (PrPres) with mAbs SAF32, SAF84, 12B2 and 9A2.


Results. To date, 2 VPSPr cases (1 MV and 1 MM) gave positive transmission in BvM109. Overall, 3 voles were positive with survival time between 290 and 588 d post inoculation (d.p.i.). All positive voles accumulated PrPres in the form of the typical PrP27–30, which was indistinguishable to that previously observed in BvM109 inoculated with sCJDMM1 cases.

In BvI109, 3 VPSPr cases (2 VV and 1 MM) showed positive transmission until now. Overall, 5 voles were positive with survival time between 281 and 596 d.p.i.. In contrast to what observed in BvM109, all BvI109 showed a GSS-like PrPSc electrophoretic pattern, characterized by low molecular weight PrPres. These PrPres fragments were positive with mAb 9A2 and 12B2, while being negative with SAF32 and SAF84, suggesting that they are cleaved at both the C-terminus and the N-terminus. Second passages are in progress from these first successful transmissions.


Conclusions. Preliminary results from transmission studies in bank voles strongly support the notion that VPSPr is a transmissible prion disease. Interestingly, VPSPr undergoes divergent evolution in the two genetic lines of voles, with sCJD-like features in BvM109 and GSS-like properties in BvI109.

The discovery of previously unrecognized prion diseases in both humans and animals (i.e., Nor98 in small ruminants) demonstrates that the range of prion diseases might be wider than expected and raises crucial questions about the epidemiology and strain properties of these new forms. We are investigating this latter issue by molecular and biological comparison of VPSPr, GSS and Nor98.


http://www.landesbioscience.com/jour...che=1216084967




Wednesday, March 28, 2012

VARIABLY PROTEASE-SENSITVE PRIONOPATHY IS TRANSMISSIBLE, price of prion poker goes up again $

http://prionopathy.blogspot.com/2012...ionopathy.html





*** The discovery of previously unrecognized prion diseases in both humans and animals (i.e., Nor98 in small ruminants) demonstrates that the range of prion diseases might be wider than expected and raises crucial questions about the epidemiology and strain properties of these new forms. We are investigating this latter issue by molecular and biological comparison of VPSPr, GSS and Nor98.




AS OF AUGUST 2012 ;

CJD UPDATE USA

1 Listed based on the year of death or, if not available, on year of referral; 2 Cases with suspected prion disease for which brain tissue and/or blood (in familial cases) were submitted; 3 Disease acquired in the United Kingdom; 4 Disease was acquired in the United Kingdom in one case and in Saudi Arabia in the other case; *** 5 Includes 8 cases in which the diagnosis is pending, and 18 inconclusive cases; *** 6 Includes 10 (9 from 2012) cases with type determination pending in which the diagnosis of vCJD has been excluded. *** The Sporadic cases include 16 cases of sporadic Fatal Insomnia (sFI) and 42 cases of Variably Protease-Sensitive Prionopathy (VPSPr) and 2224 cases of sporadic Creutzfeldt-Jakob disease (sCJD).


http://www.cjdsurveillance.com/pdf/case-table.pdf




Tuesday, November 6, 2012

Transmission of New Bovine Prion to Mice, Atypical Scrapie, BSE, and Sporadic CJD, November-December 2012 update

http://transmissiblespongiformenceph...-prion-to.html





Friday, November 23, 2012

sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA, AND CANADA

snip...

Greetings BSE-L members et al, and others,

Confucius is confused again on the infamous ‘classification pending sporadic creutzfeldt jakob disease’ cpsCJD, (because nvCJD has been ruled out).

Confucius is confused about why the increase of these cpsCJD cases in the USA and Canada which we have been seeing, but I saw no reports in the UK surveillance reports of the infamous North American Classification Pending Sporadic Creutzfeldt Jakob disease cases.

if truly a supposedly sporadic spontaneous disease, would you not see these cpsCJD cases popping up all over the world in random ???

or, could these cpsCJD cases be of a North American zoonotic or iatrogenic from North American zoonoses sub-clinical source ???

or both ???

with so many documented Transmissible Spongiform Encephalopathy TSE prion disease in so many different species here in North America, and consumption there from, I believe that this should be at the forefront of research. ...


Confused Confucius...flounder


snip...see full text ;




Friday, November 23, 2012

sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA, AND CANADA

http://creutzfeldt-jakob-disease.blo...b-disease.html




Saturday, October 6, 2012

TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES 2011 Annual Report

http://transmissiblespongiformenceph...ation-and.html




Wednesday, May 16, 2012

Alzheimer’s disease and Transmissible Spongiform Encephalopathy prion disease, Iatrogenic, what if ?

Proposal ID: 29403

http://betaamyloidcjd.blogspot.com/2...smissible.html



see the Duke, Pa, Yale, and Mexican study here, showing the misdiagnosis of CJD TSE prion disease as Alzheimers ;


http://betaamyloidcjd.blogspot.com/2...ho-really.html



Monday, August 20, 2012


CASE REPORTS CREUTZFELDT-JAKOB DISEASE: AN UNDER-RECOGNIZED CAUSE OF DEMENTIA


http://creutzfeldt-jakob-disease.blo...b-disease.html





Thursday, August 02, 2012

CJD case in Saint John prompts letter to patients

Canada CJD case in Saint John prompts letter to patients

http://creutzfeldt-jakob-disease.blo...ts-letter.html




layperson



TSS




Sunday, December 2, 2012

CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE BLEW IT’

http://madcowtesting.blogspot.com/20...w-disease.html