I talked with Kathlee's Dr. yesterday. He changed her dose of Amitiza (for the constipation) and prescribed Periactin for the pain. Of course I've been looking at everything I can about the drug. It's an antihistimine and is commonly used as an apetite stimulant. This could be a big problem for Kathleen since she has so many orthopedic issues that could be worse if she gains weight. She won't understand that she can't eat constantly if this makes her as hungry people have said. It also seems it makes people very sleepy another potential problem since she already becomes exhausted very easily. She's starting with a very small dose (first one last night). She woke up this morning VERY irratable and had 2 hot baths within a couple hours. I've been trying to find information on this in regards to vascular respone since it's an antihistimine. We've avoided antihistimines in the past since they can be vascular constrictors. Not a good thing for someone with moyamoya. Keeping my fingers crossed I jsut hate trying new drugs there are so many things she can't communicate to me that she may feel... i'll lelt you know how this is working out.