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Thread: Will the real multiple sclerosis please stand up?

  1. #1

    Default Will the real multiple sclerosis please stand up?

    hello all! the title's the name of an article i saw on a british site. i can find the art., but can't get in it - not a member. can't find it in its entirety anywhere on the web, either. but did find this:

    http://www.nature.com/nrn/journal/v1...rn3275_F1.html

    a nice little drawring, and a link to the unreachable article. not the first time this theory's been put forth. i wonder if it addresses, in any fashion, the female/male frequency of disease difference?

    hope it will all be revealed in the near future.

    best,

    h.

  2. #2
    Distinguished Community Member agate's Avatar
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    I don't have access to that journal either, but this abstract from PubMed (May 18, 2012) may be of some interest:

    Neurology. 2012 May 16.

    Rising incidence of multiple sclerosis in females associated with urbanization

    Kotzamani D, Panou T, Mastorodemos V, Tzagournissakis M, Nikolakaki H, Spanaki C, Plaitakis A.

    From the Department of Neurology (D.K., T.P., V.M., M.T., C.S., A.P.), School of Medicine, University of Crete, Heraklion; and 2 Neurological Department at the General Hospital (H.N.), Chania, Crete, Greece.

    OBJECTIVE:

    To design and perform a case-control study of multiple sclerosis (MS) in Crete, an island of 0.6 million people, that has experienced profound socioeconomic changes in recent decades.

    METHODS:

    All MS cases occurring on Crete from 1980 to 2008 were ascertained. To search for putative risk factors, a structured questionnaire of 71 variables was employed, with patients with MS (n = 657) being compared to random controls (n = 593) matched for age, gender, and current place of residence.

    RESULTS:

    MS incidence rose markedly on Crete over the past 3 decades. This increase was associated with a major shift in MS distribution among genders (1980: F/M = 0.9; 2008: F/M = 2.1), with females living in towns or having relocated at a young age from the countryside to urban centers being mainly affected.

    In rural Crete, MS showed lesser increases and gender preference.

    Of the major changes that accompanied urbanization, smoking among women with MS increased dramatically, while imported pasteurized cow milk virtually replaced fresh goat milk produced locally.

    Compared to controls, female patients with MS more often used contraceptives and were older at first childbirth.

    Besides smoking, alcohol drinking and vitamin intake was more common among female patients with MS.

    Also, the distribution of childhood diseases and chronic medical conditions differed significantly between patients with MS and controls.

    CONCLUSIONS:

    MS incidence rose markedly over 3 decades in a genetically stable population in tandem with a transition from rural to urban living, thus possibly implicating environmental factors introduced by urbanization.

    PMID:22592376
    http://www.ncbi.nlm.nih.gov/pubmed/22592376

    I couldn't get the text out of italics--sorry!
    Last edited by agate; 07-04-2012 at 10:22 PM.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    If ONLY someone could figure out exactly what we have then there might be a chance of helping us more.
    Virginia

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