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Discovery May Lead to New Treatment for ALS

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    Discovery May Lead to New Treatment for ALS

    Researchers at Oregon Health & Science University School of Dentistry have discovered that TDP-43, a protein strongly linked to ALS (amyotrophic lateral sclerosis) and other neurodegenerative diseases, appears to activate a variety of different molecular pathways when genetically manipulated. The findings have implications for understanding and possibly treating ALS and neurodegenerative diseases such as Alzheimer's and Parkinson's.

    ALS affects two in 100,000 adults in the United States annually and the prognosis for patients is grim.The new discovery is published online in G3: Genes, Genomes, Genetics (and the July 2012 print issue of G3).

    Using a fruit fly model, the OHSU team genetically increased or eliminated TDP-43 to study its effect on the central nervous system. By using massively parallel sequencing methods to profile the expression of genes in the central nervous system, the team found that the loss of TDP-43 results in widespread gene activation and altered splicing, much of which is reversed by rescue of TDP-43 expression. Although previous studies have implicated both absence and over expression of TDP-43 in ALS, the OHSU study showed little overlap in the gene expression between these two manipulations, suggesting that the bulk of the genes affected are different.

    "Our data suggest that TDP-43 plays a role in synaptic transmission, synaptic release and endocytosis," said Dennis Hazelett, Ph.D., lead author of the study. "We also uncovered a potential novel regulation of several pathways, many targets of which appear to be conserved."


    Only registered and activated users can see links., Click Here To Register...
    Yet inside there is this perpetual nagging doubt;
    the feeling we are possessed by a 'subtle lack of togetherness''.

    #2
    Prot, the link to the website is not working. Would you be so kind as to double check? My husband is being tested with ALS as a possible diagnosis.

    Gabriella
    Last edited by Gabriella7; 07-21-2012, 10:48 AM.
    Progressive/Relapsing MS, Myasthenia Gravis, Spinal Stenosis, Degenerative Disc Disease, Diabetes, Hypertension, Hashimoto's Thyroiditis
    Advocate for ADA, Artist's Community for Change, ADAPT, Universal Living in Place, HopeKeepers, Complementary and Alternative Medicine

    "Life is mostly froth and bubble, two things stand like stone. Kindness in another's trouble, Courage in your own"........Adam Lindsay Gordon

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      #3
      It works for me Gabriella. Very interesting article.
      Question: Why can't I post links or pictures?
      Question: Why can't I have a signature, avatar, or profile picture?
      Question: What's wrong with my account?

      Answer: You are in the "registered users" user group. This group is very limited in what it can do. This will annoy spammers to no end Just keep posting once you have been registered for 30 days and have made 11 posts your account will be "unlocked".

      It's really easy to put someone on ignore and it's strongly recommended that you do so with people who's posts you don't like.

      Step 1 - log in
      Step 2 - click on the "settings" link
      Step 3 - click on the "edit ignore list" link on the left side of the screen
      Step 4 - type (or paste if you copied and pasted it) the username of the person you want to ignore
      Step 5 - click the "ok" button on the right of the screen

      Easy peasy and will lower your blood pressure. One important note though, this won't hide quoted posts. It's an oversight on the developers part and it's not an easy thing to "fix." So if someone quotes someone you have ignored, you'll see the quote.

      Alternatively when you click on a person's name and view their profile page, underneath their avatar, there is a option that says, "Ignore this person". Click that link and then click the yes button.

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        #4
        Link Worked for Me

        ((((((Gabriella))))))

        Here is the link again:


        Only registered and activated users can see links., Click Here To Register...


        To copy and paste, use Only registered and activated users can see links., Click Here To Register....

        followed by

        sciencedaily.com/releases/2012/07/120718172402.htm

        OR

        Go to Only registered and activated users can see links., Click Here To Register...

        and use the Search on their site. Type ALS in the search box. Several articles are listed.

        This article's date is July 18, 2012.

        Hope this helps you.

        Love & Light,

        Rose
        Mom to Jon, 49, & Michael, 32, born with an undiagnosed progressive neuromuscular disease. Angel Michael received his wings in 2003. Angel Jon received his wings in 2019. In 2020, Jim, their Dad, joined them.

        Comment


          #5
          Thanks for the links, the clitch must have been on my end. I'll read all of the articles tomorrow when I am rested.

          Gabriella
          Progressive/Relapsing MS, Myasthenia Gravis, Spinal Stenosis, Degenerative Disc Disease, Diabetes, Hypertension, Hashimoto's Thyroiditis
          Advocate for ADA, Artist's Community for Change, ADAPT, Universal Living in Place, HopeKeepers, Complementary and Alternative Medicine

          "Life is mostly froth and bubble, two things stand like stone. Kindness in another's trouble, Courage in your own"........Adam Lindsay Gordon

          Comment


            #6
            Gabriella, if you happen to come back by please go to the MS forum and read what I wrote about the VA (if your husband happens to have served at anytime in the military). It could be something of importance to you. It is under your ALS thread.

            Virginia
            Virginia

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