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Old 11-07-2006, 07:56 PM
klasyjo klasyjo is offline
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Posts: 39
Question HLA testing

When your doctors ordered your gene testing for the HLA, did they ask for only a specific test or did they ask for HLA-A, B, C, DR, DQ, DP?

I've had only three done:
B27 negative
DQ 2 positive
DQ 8 negative

I know that different HLA genes can create/affect different diseases. DQ & DR are with Celiac. I'm in the process of getting information about which gene affects which disease.

Thanks, Just curious & learning.
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Becki

Hashimotos, Ehlers-Danlos Syndrome Hyper-mobility Type III, Osteoarthritis C5-6-7 L4-5 S1 w/slight narrowing of disk space, Pre-Osteopenia in both hips, Herniated Disks T8-9, Cervical Lordosis, Sciatica, Facet Arthropathy, Sinus Polyps, Lymphadenopathy, Migraines, Spina Bifida Occulta and Celiac Spru
Vitamin deficiencies B1, B6, Carnitine and Magnesium
Allergies: Morphine, Demerol, Darvocet, Vikadon, Ultram/Tramadol, Sulfate, Duragestic
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Old 11-07-2006, 08:09 PM
NancyM NancyM is offline
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Posts: 381
Default

HLA B27 is the one they do for diagnosing ankylosing spondylitis. I'm positive on that one.
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  #3  
Old 11-07-2006, 10:14 PM
klasyjo klasyjo is offline
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Join Date: Oct 2006
Posts: 39
Default which gene affects which disease

I found some information:

http://www.questdiagnostics.com/bran...u_gen/faq.html

http://www.cdc.gov/ncidod/eid/vol3no1/singh.htm

http://www.thyroidmanager.org/Chapter7/7-text.htm
refer to part 3. Antigen Presentation On MHC Molecules, complex but does have good info

http://www.jci.org/cgi/content/full/116/8/2226
specific to Celiac

http://www.uchsc.edu/misc/diabetes/oxch8.html
I found this interesting because I can now go to my mother w/proof that her addison's disease is linked to my Celiac by the HLA DQ 2

http://www.endotext.org/diabetes/dia.../diabetes5.htm
Interesting notation in the link:
Quote:
When an individual presents with type 1A diabetes it indicates that they and their relatives have an increased risk of having or developing a series of autoimmune disorders(11). Celiac disease, hypothyroidism, hyperthyroidism, Addison’s disease and pernicious anemia are some of the most prominent associated diseases. For example approximately 1/20 patients with type 1 diabetes have celiac disease(13;14). Most of these patients are asymptomatic and the disorder is only discovered if anti-transglutaminase autoantibodies are measured and individuals with positive antibodies biopsied. In that the therapy for celiac disease, namely gluten avoidance, is highly effective, at the Barbara Davis Center we routinely screen all type 1 diabetic patients. We also screen for thyroid disease and for Addison’s disease (21-hydroxylase autoantibodies)(15).
http://www.annals.org/cgi/reprint/142/4/289.pdf
specific to celiac - very good
__________________
Becki

Hashimotos, Ehlers-Danlos Syndrome Hyper-mobility Type III, Osteoarthritis C5-6-7 L4-5 S1 w/slight narrowing of disk space, Pre-Osteopenia in both hips, Herniated Disks T8-9, Cervical Lordosis, Sciatica, Facet Arthropathy, Sinus Polyps, Lymphadenopathy, Migraines, Spina Bifida Occulta and Celiac Spru
Vitamin deficiencies B1, B6, Carnitine and Magnesium
Allergies: Morphine, Demerol, Darvocet, Vikadon, Ultram/Tramadol, Sulfate, Duragestic
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