BrainTalk Communities 10/2006-8/2011 Archives  

Go Back   BrainTalk Communities 10/2006-8/2011 Archives > Specific Neurological Conditions (M - Z) > Multiple Sclerosis

Reply
 
Thread Tools Display Modes
  #1  
Old 10-16-2006, 09:16 AM
xo++ xo++ is offline
Distinguished Community Member
 
Join Date: Oct 2006
Posts: 306
Default New improved "Copaxone" beginning clinical trials in MS

As many of you probably know, Copaxone was discovered by accident. Researchers were actually trying to develop a drug which induced EAE, the rodent version of MS, but found instead that the mice were protected by the drug.

Researchers at Harvard for the past six or seven years have been trying to create an updated version of Copaxone and may have succeeded. Clinical trials in humans are now beginning. These researchers have been looking closely at what they believe makes Copaxone work, and incorporating that knowledge into a new and improved version.

Copaxone is composed of four amino acids, but the researchers found that dropping one of these amino acids and adding a different one created a much more effective drug, based on animal studies and based on exposing human T-cells (which attack myelin) to the new combination.

Because of its (apparent) greater effectiveness, the drug would only need to be injected once per week, subcutaenously.

Peptimmune is developing the drug (not Teva).

Here is an abstract from ECTRIMS 2006 on the drug:

Immunomodulation of experimental autoimmune encephalomyelitis by the novel copolymer PI-2301

B. Carrillo-Rivas, J.T. Kovalchin, J. Krieger, M. Augustyniak, I. Dufour, K. Johnson, H.M. Genova, K. Rafuse, A. Ward, S. Baldwin, R. Kolbeck, J-C. Gutierrez-Ramos, E. Zanelli (Cambridge, USA)

Years of clinical experience have shown that daily subcutaneous administration of the peptide copolymer Copaxoneâ„¢ (Cop-1), a mixture of millions of peptides composed of the four amino acids YEAK in random order, is a safe and efficacious treatment for relapsing-remitting multiple sclerosis (RR-MS).

Cop-1 was modeled to mimic myelin basic protein (MBP) and turned out to ameliorate experimental autoimmune encephalomyelitis (EAE) in mice, most likely by shifting the immune response away from an effector TH1 to an immunoregulatory TH2/TH3 immune response through presentation by MHC class II molecules.

Recently, a series of new peptide copolymers have been synthesized with the goal to improve the in vivo efficacy of Cop-1. In the present study, we show that Copolymer PI-2301 produced by substituting E with F has improved beneficial effects in a relapsing-remitting murine model of EAE.

Unlike Cop-1, PI-2301 shows long-term therapeutic efficacy when administered either daily or weekly at disease onset. In an adoptive EAE setting, efficacy of PI-2301 administered daily at the time of autoreactive lymph node cell transfer correlates with decreased serum level of Metalloproteinase-9 and increased level of Metalloproteinase Inhibitor-1.

Antibody production against PI-2301 and T-cell recall proliferation assay using splenocytes from PI-2301-treated mice underscore the induction of a TH2/TH3 immunity. Evidences of the expansion of T-cells with regulatory properties expressing Forkhead box protein P3 (FoxP3) and producing Interleukin-10 following PI-2301 treatment are also apparent.

We propose that PI-2301 is a potential novel immunomodulatory compound for the treatment of RR-MS. Clinical trials will soon be started to test this hypothesis.
_____________

And here are a few prior research papers detailing the progress made:

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis.

Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses.

Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.

Copolymer effects on microglia and T cells in the central nervous system of humanized mice.

Mark
Reply With Quote
  #2  
Old 10-16-2006, 12:20 PM
stitch stitch is offline
New Community Member
 
Join Date: Oct 2006
Location: Canada
Posts: 8
Default

Thanks Mark. Very interesting information.

It would be wonderful to cut out 6 shots each week. It's a long way off but the change in life quality for those on C would certainly be improved.
Reply With Quote
  #3  
Old 10-16-2006, 02:04 PM
Lazarus Lazarus is offline
Distinguished Community Member
 
Join Date: Oct 2006
Location: western MA
Posts: 612
Default thank you

I appreciate your posts so much. This one is perfect timing as I have an appt. on wednesday.

I wonder why TEVA is not producing it...maybe the companies are connected.

Linda
__________________
Linda~~~~

Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"
Reply With Quote
  #4  
Old 10-16-2006, 04:06 PM
*Joy* *Joy* is offline
Distinguished Community Member
 
Join Date: Oct 2006
Posts: 378
Default

Thank you, Mark. My doctor has mentioned this to me before. I've been waiting to hear more about this.

Has the clinical trial started yet?

Linda, best of luck with your appointment on Wednesday.
__________________
Joy

Multiple Sclerosis and Trigeminal Neuralgia - Currently on Tysabri
Reply With Quote
  #5  
Old 10-16-2006, 06:01 PM
BBS1951 BBS1951 is offline
Distinguished Community Member
 
Join Date: Oct 2006
Posts: 2,389
Default

Thanks for the news.

And, also, I did not know that was how Copaxone was discovered as an MS therapy.
Reply With Quote
  #6  
Old 10-16-2006, 08:42 PM
MarciaK2 MarciaK2 is offline
New Community Member
 
Join Date: Oct 2006
Posts: 22
Default

Thanks for the encouraging news, Mark. And for all of your other updates.

Marcia
aka MarciaK1 & ancestrynut
Reply With Quote
  #7  
Old 10-17-2006, 01:16 AM
Ruby_NikitaK9 Ruby_NikitaK9 is offline
Distinguished Community Member
 
Join Date: Oct 2006
Posts: 609
Default

My Injection Sites Thank you for posting this
__________________
Relapsing Remmiting MS Copaxone since August 2005

[SIGPIC][/SIGPIC]I will never forget my dearest doggy Ruby who taught me how to never give up... to make the best out of what you have and keep trying... I love you my bestest girl...
Reply With Quote
  #8  
Old 10-17-2006, 05:46 PM
xo++ xo++ is offline
Distinguished Community Member
 
Join Date: Oct 2006
Posts: 306
Default

Linda, I don't think there is any reason TEVA would be involved -- although the drug was designed to be a more effective version of Copaxone, any pharmaceutical could have done the research and come up with the new version. So I don't believe there would be any patent issues.

In some ways the Canadian drug entering phase II/III trials -- MBP8298 -- also reminds me of Copaxone, although it is composed of 17 amino acids. One of the trial requirements is that patients not be allergic to Copaxone.

Joy, the company states at their website that the clinical trial is to begin this year, but I haven't found any recruitment information.

Mark
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
"sugar free" actiq......................FENTORA paigiesmom Chronic Pain 20 05-30-2008 08:38 PM
Asperger's Syndrome - "Aspie" - Attwood and Gray Lara Autism 7 10-13-2006 09:34 AM
Hey, spineys...long time no "see" JLW Spinal Disorders 4 10-10-2006 05:24 PM
OT: Paddle Steamer "Waverley" HelenEdith Headache & Migraine 3 10-03-2006 05:25 PM


All times are GMT -4. The time now is 04:27 PM.


Powered by vBulletin® Version 3.8.5
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
BrainTalk Communities Incorporated